My Children Aren't Speaking..

I am 49 years old, married for 26 years, and have 2 children ages 18 and 23. I have been in treatment for depression for the past 7 years. I am on medications, and they help the depression, but I just have this empty feeling and feel like my life has been a failure; I don't see the future getting any better. My children are not speaking to each other since my 18 year old son married a 22 year old woman, quit school, and moved out of state; he now has a child. My daughter was verbally abusive to his wife prior to them leaving. I miss him terribly and am greatly distressed that their relationship has been damaged by these events. Should I allow them to work this out by themselves? I am afraid the longer it goes on, the less likely it is that they will reconcile. What can I say or do that might help them get back to at least a speaking relationship? My daughter is getting married in one month and he won't come to the wedding.

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